Boron trifluoride etherate → N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane

HRID 746187

반응식

HRID 746187 반응식
[C:1]([N:11]1[CH2:13][CH:12]1[CH3:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[C:15]([CH:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[OH:20])([CH3:18])([CH3:17])[CH3:16].B(F)(F)F.CCOCC.C([O-])(O)=O.[Na+]>C(Cl)Cl>[C:1]([NH:11][CH:12]([CH3:14])[CH2:13][O:20][CH:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[C:15]([CH3:18])([CH3:17])[CH3:16])([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]

참가 물질

6

반응물 4

HCID 8000Boron trifluoride etherateHCID 1397902,2,4,4-Tetramethylpentan-3-olHCID 516892Sodium BicarbonateHCID 21895246Benzyl 2-methylaziridine-1-carboxylate

생성물 1

HCID 20201216N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-Cbz-2-Methyl aziridine and di-t-butylmethanol are dissolved in CH2Cl2 at 0° C. under argon. Boron trifluoride etherate is added and the flask is stirred overnight. The contents are poured into saturated NaHCO3 and are extracted with ethyl acetate. The organic layer is drid over MgSO4 and evaporated to yield N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane.

후처리

  1. extractionare extracted with ethyl acetate
  2. customevaporated

출처 및 근거

ORD 기록
ord-a314b7ccc7ef4bcc8f231c992f29236a
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04603011

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