Pivalaldehyde → 2,2,4,4-Tetramethylpentan-3-ol

HRID 746189

반응식

HRID 746189 반응식
[CH3:1][C:2]([CH3:6])([CH3:5])[CH:3]=[O:4].[C:7]([Li])([CH3:10])([CH3:9])[CH3:8]>O1CCCC1>[C:2]([CH:3]([C:7]([CH3:10])([CH3:9])[CH3:8])[OH:4])([CH3:6])([CH3:5])[CH3:1]

참가 물질

4

반응물 2

HCID 12417PivalaldehydeHCID 178418306HCID 178418306, 화합물

생성물 1

HCID 1397902,2,4,4-Tetramethylpentan-3-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of trimethylacetaldehyde (5.12 g, 59.4 mmol) in anhydrous tetrahydrofuran (15 ml) at -78° C. under an argon atmosphere is added 40.9 ml of a solution of t-butyllithium in hexanes (1.6M, 65.4 mmol). The mixture is allowed to warm from -78° to room temperature over 2 hours. The reaction is quenched with 25 ml of 1M hyrochloric acic and the resulting mixture extracted with two 25 ml portions of ether. The combined ethereal extracts were washed with saturated sodium bicarbonate solution and water, dried over magnesium sulfate, and the solvent evaporated to yield a yellow oil (9.3 g) which is purified by vacuum distillation to yield a colorless oil.

후처리

  1. temperatureto warm from -78° to room temperature over 2 hours
  2. customThe reaction is quenched with 25 ml of 1M hyrochloric acic
  3. extractionthe resulting mixture extracted with two 25 ml portions of ether
  4. washThe combined ethereal extracts were washed with saturated sodium bicarbonate solution and water
  5. dry with materialdried over magnesium sulfate
  6. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-b51e38b89b8a4eb4ae0ac0a01d7c086a
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04603011

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