Triethylamine → HCID 58386394, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	2,3,4,5-Tetrahydro-1H-benzo(d)azepine	HCID 1400243	—
반응물	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
반응물	6-[4-(2-Oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]pyrimidine-4-carboxylic acid	HCID 58386696	—
용매	Dimethylformamide	HCID 6228	—
생성물	HCID 58386394	HCID 58386394	—

반응 단계

100.0 mg (0.29 mmol) 6-[4-(2-oxo-2,3-dihydro-imidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid, 50.0 mg (0.34 mmol) 2,3,4,5-tetrahydro-1H-3-benzazepine, 100 μL (0.71 mmol) triethylamine and 100.0 mg (0.31 mmol) TBTU in 1.5 mL DMF were stirred overnight at RT. The reaction mixture was filtered through a syringe filter and the solution was purified by preparative HPLC. The product fractions were combined and lyophilised.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08829006B2
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-6f9496dd18b0417d81a00c7a0f295a62
출처 메모	uspto-grants-2014_09