홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Carbonate → 2-(4-Pyridinyl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

HRID 746454
노트
인쇄 미리보기

반응식

HRID 746454 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH2:8][C:9]([O:11]CC)=O)=[CH:3][CH:2]=1.Cl.[F:16][C:17]([F:26])([F:25])[CH:18]1[NH:23][C:22]([NH2:24])=[N:21][CH2:20][CH2:19]1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[N:24]=[C:22]3[NH:23][CH:18]([C:17]([F:26])([F:16])[F:25])[CH2:19][CH2:20][N:21]3[C:9](=[O:11])[CH:8]=2)=[CH:5][CH:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 2735202Ethyl 3-(4-pyridyl)-3-oxopropionateHCID 230261764-(Trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-2-amine hydrochloride

생성물 1

HCID 1363464562-(4-Pyridinyl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one수율 55.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 5.62 g (29.09 mmol) of ethyl 3-(pyridin-4-yl)-3-oxopropionate, 7 g (29.09 mmol) of 6-(trifluoromethyl)-1,4,5,6-tetrahydro-2-pyrimidinamine hydrochloride (1:2) and 10.05 g (72.72 mmol) of potassium carbonate in 50 ml of ethanol was heated at reflux temperature for 12 h. The cooled solution was evaporated to remove solvent, the residue was treated with water and the precipitate was filtered to give 4.82 g of product as a yellow powder.

후처리

  1. temperaturewas heated
  2. temperatureat reflux temperature for 12 h
  3. customThe cooled solution was evaporated
  4. customto remove solvent
  5. additionthe residue was treated with water
  6. filtrationthe precipitate was filtered

출처 및 근거

ORD 기록
ord-f6940863ce4649aabacc1459b04f40eb
출처 데이터셋
uspto-grants-2008_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07393853B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트