Potassium Carbonate → Benzooxazol-6-yl-(6-bromo-imidazo[1,2-a]pyrazin-8-yl)-amine

HRID 746460노트

반응식

HRID 746460 반응식
[O:1]1[C:5]2[CH:6]=[C:7]([NH2:10])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[Br:11][C:12]1[N:13]=[C:14](Br)[C:15]2[N:16]([CH:18]=[CH:19][N:20]=2)[CH:17]=1.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[O:1]1[C:5]2[CH:6]=[C:7]([NH:10][C:14]3[C:15]4[N:16]([CH:18]=[CH:19][N:20]=4)[CH:17]=[C:12]([Br:11])[N:13]=3)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 5841201,3-Benzoxazol-6-amineHCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

생성물 1

HCID 57447606Benzooxazol-6-yl-(6-bromo-imidazo[1,2-a]pyrazin-8-yl)-amine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A quantity of 0.13 g (1 mmole) of Benzooxazol-6-ylamine is treated with 0.27 g (1 mmole) of 6,8-Dibromo-imidazo[1,2-a]pyrazine in acetonitrile with 3 eq of K2CO3 at reflux for 16 hrs. The reaction mixture is cooled partitioned between ethyl acetate and water, the organic extracts are dried over anhydrous MgSO4 and evaporated in vacuo to afford benzooxazol-6-yl-(6-bromo-imidazo[1,2-a]pyrazin-8-yl)-amine.

후처리

  1. temperatureat reflux for 16 hrs
  2. temperatureThe reaction mixture is cooled
  3. custompartitioned between ethyl acetate and water
  4. dry with materialthe organic extracts are dried over anhydrous MgSO4
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-d0cc7d22717641669e8707a51a6d8639
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07393848B2

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