3-Chlorophenylboronic acid ethylene glycol ester → (3-Chlorophenyl)(3,4-dimethoxyphenyl)borinic acid

HRID 746478노트

반응식

HRID 746478 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([Mg]Br)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[B:13](OCCO)([OH:21])[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=1>>[Cl:20][C:16]1[CH:15]=[C:14]([B:13]([C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[OH:21])[CH:19]=[CH:18][CH:17]=1

참가 물질

3

반응물 2

HCID 692083603-Chlorophenylboronic acid ethylene glycol esterHCID 178491916HCID 178491916, 화합물

생성물 1

HCID 69207503(3-Chlorophenyl)(3,4-dimethoxyphenyl)borinic acid

실험 절차

(3-Chlorophenyl)(3,4-dimethoxyphenyl)borinic acid was prepared from 3,4-dimethoxyphenylmagnesium bromide and 3-chlorophenylboronic acid ethylene glycol ester by the procedure described in Example 6a. The title complex product was made by the methodology described in Section 5.3.7.1, and obtained as yellow crystals. MS (ESI, positive): m/z=404 (M+1); 1H NMR (DMSO-d6, 300 MHz): δ 9.17 (d, 1H), 8.78 (d, 1H), 7.90 (dd, 1H), 7.70 (t, 1H), 7.43 (d, 1H), 7.30-7.17 (m, 5H), 6.89-6.80 (m, 3H), 3,66 (s, 3H) and 3.62 (s, 3H) ppm.

후처리

  1. customobtained as yellow crystals

출처 및 근거

ORD 기록
ord-44af01f9e8b24b36b3e2c4716540a207
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07393856B2

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