2,3-Dihydroxybutanedioic Acid → (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate
반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:15]([CH3:17])[CH3:16])[CH:12]([CH3:14])[CH3:13])[CH:7]=1.[C:25]([OH:34])(=[O:33])[CH:26]([CH:28]([C:30]([OH:32])=[O:31])[OH:29])[OH:27]>C(OCC)(=O)C>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:12]([CH3:14])[CH3:13])[CH:15]([CH3:16])[CH3:17])[CH:7]=1.[CH:26]([OH:27])([C:25]([OH:34])=[O:33])[CH:28]([OH:29])[C:30]([OH:32])=[O:31]참가 물질
4
실험 절차
Tolterodine free base (2.0 gm) is dissolved in ethyl acetate (25 ml) and tartaric acid (1.2 gm) is added to the solution. Then the contents are maintained for 2 hours at 25° C. to 30° C. and filtered to give 2.2 gm of tolterodine tartrate form II.