Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bms-973013 → 1-[4'-(4,5-Difluoro-2,3-dihydro-indole-1-carbonyl)-6'-methoxy-3,4,5,6-tetra-hydro-2H-[1,2]bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bms-973013 | HCID 22293182 | — |
| 반응물 | (2-Chloro-6-methoxy-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone | HCID 58386617 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 1-[4'-(4,5-Difluoro-2,3-dihydro-indole-1-carbonyl)-6'-methoxy-3,4,5,6-tetra-hydro-2H-[1,2]bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one | HCID 42614090 | — |
반응 단계
0.98 g (4.5 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one and 0.50 g (1.5 mmol) (2-chloro-6-methoxy-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone were stirred in 3 mL NMP for 12 h at 130° C. The reaction mixture was purified by HPLC. The product-containing fractions were combined and freeze-dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829006B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-4e9e9e24fba74d249831f2961372b84b |
| 출처 메모 | uspto-grants-2014_09 |