참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | 2-Propanesulfonyl chloride | HCID 82408 | — |
| 반응물 | 2-(4'-Bromophenyl)aniline | HCID 11368633 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 57974945 | HCID 57974945 | 75.3% |
반응 단계
Add 4′-bromo-biphenyl-2-ylamine (1.038 g, 4.183 mmol) to CH2Cl2 and cool to 0° C. Add first DBU (2.6 ml, 17.038 mmol), then isopropylsulfonyl chloride (0.95 ml, 8.206 mmol) drop wise to flask and warm flask to room temperature. After 18 hours monitor reaction. If SM is still present, add DBU (1 ml), then isopropylsulfonyl chloride (0.4 ml) and then stir 2 additional hours. Purify resultant product using flash chromatography (Silica gel-25% EtOAc/Hexane) to provide propane-2-sulfonic acid (4′-bromo-biphenyl-2-yl)-amide (1.116 g, 75%). MS(m/e): 351.9(M−1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07393868B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_07 |
|---|
| ORD ID | ord-4d3690aded9b44a298c16f635dbc3d8a |
|---|
| 출처 메모 | uspto-grants-2008_07 |
|---|
