Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Chloride → 4-Bromo-3-(methanesulfonylamino)-benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sodium Sulfate | HCID 24436 | — |
| 반응물 | Methyl 3-amino-4-bromobenzoate | HCID 3928639 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Bromo-3-(methanesulfonylamino)-benzoic acid methyl ester | HCID 69254444 | — |
반응 단계
Add Na2SO4 (0.12 mmol) to a suspension of 4-Bromo-3-amino-benzoic acid methyl ester (0.1 mmol) and Et3N (0.1 mmol) in dichloromethane at 0° C. Stir 4 h at RT. Add a saturated solution of NaCl (15 mL), and extract with dichloromethane (2×50 mL). Dry over NaSO4, filter and evaporate to dryness. Purify the residue utilizing flash chromatography (Silica gel-hexane/EtOAc) to provide the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07393868B2 |
| 출처 데이터셋 | uspto-grants-2008_07 |
| ORD ID | ord-b097c323dd0c44d9ba4d4ac2d7d18996 |
| 출처 메모 | uspto-grants-2008_07 |