Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 4-Bromo-2,6-difluoroanisole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Bromo-2,6-difluorophenol | HCID 2736292 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 4-Bromo-2,6-difluoroanisole | HCID 2773287 | — |
반응 단계
Add iodomethane (2.0 ml, 32.1 mmol) dropwise to a suspension of 4-bromo-2,6-difluorophenol (5.90 g, 28.2 mmol) and potassium carbonate (4.40 g, 31.8 mmol) in acetone (50 ml) at room temperature while stirring vigorously. Heat the mixture under reflux overnight. Evaporate acetone and add dichloromethane. Filter through silica eluting the product with dichloromethane/EtOAc. Concentrate to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07393868B2 |
| 출처 데이터셋 | uspto-grants-2008_07 |
| ORD ID | ord-a291ed1aa0994e328206e6d5aeacc4dc |
| 출처 메모 | uspto-grants-2008_07 |