Sodium Carbonate → Propane-2-sulfonic acid {2-[4'-(2-hydroxy-ethyl)-biphenyl-4-yl]-thiophen-3-yl}amide

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Carbonate	HCID 10340	—
반응물	2-(4-Bromophenyl)ethanol	HCID 72851	—
반응물	Propane-2-sulfonic acid {2-[4-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-phenyl]-thiophen-3-yl}-amide	HCID 59747992	—
용매	Ethanol	HCID 702	—
용매	1,2-Dimethoxyethane	HCID 8071	—
생성물	Propane-2-sulfonic acid {2-[4'-(2-hydroxy-ethyl)-biphenyl-4-yl]-thiophen-3-yl}amide	HCID 90690755	—

반응 조건

온도	92.5 °C

반응 단계

Mix propane-2-sulfonic acid{2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-thiophen-3-yl}-amide (0.10 g), 0.1 equiv of tetrakis triphenylphosphine palladium (0), 2 equiv of 2M sodium carbonate aqueous solution in DME (2 mL) and EtOH(1 mL) and warm to 90-95° C. After warming two min, add 2-(4-bromo-phenyl)-ethanol (1.3 equiv) and stir at that temperature for 1.5 h. Evaporate solvents over Celite® and purify by silica gel Strata® cartridges eluting with hexanes-EtOAc gradient to give 0.041 g of the title compound. MS (ES+) (m/z): 402 (M+1).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07393868B2
출처 데이터셋	uspto-grants-2008_07
ORD ID	ord-97b0e8c9c2a14cf698b75686a82e6caa
출처 메모	uspto-grants-2008_07