HCID 22278860, 화합물 → 4-Dimethylamino-3-ethyl-3-methylpiperidine

HRID 746890노트

반응식

HRID 746890 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:16])[CH3:15])[C:10]([CH2:18][CH3:19])([CH3:17])[CH2:9]1)C1C=CC=CC=1>CO.[H][H].[OH-].[OH-].[Pd+2]>[CH3:15][N:14]([CH3:16])[CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][C:10]1([CH2:18][CH3:19])[CH3:17]

참가 물질

5

반응물 1

HCID 22278860HCID 22278860, 화합물

생성물 1

HCID 222788404-Dimethylamino-3-ethyl-3-methylpiperidine

시약·촉매·용매 3

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매HCID 178418361HCID 178418361, 화합물용매

실험 절차

A mixture of 20% Pd(OH)2 on carbon (0.7 g) and 1-benzyl-4-dimethylamino-3-ethyl-3-methyl piperidine (6 g, 23 mmol) in methanol (50 ml) was stirred in hydrogen atmosphere (1 atm.) for 48 hr at room temperature. The catalyst was filtered off, washed with methanol and filtrate was concentrated to afford 4-dimethylamino-3-ethyl-3-methylpiperidine. Yield 2.8 g (72%), C10H22N2, m/z 171 (M+1).

후처리

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol and filtrate
  3. concentrationwas concentrated

출처 및 근거

ORD 기록
ord-4120684042c6486aaceb659f623574b5
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07393957B2

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