HCID 69148474, 화합물 → 4-Hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane

HRID 747020노트

반응식

HRID 747020 반응식
[OH:1][CH:2]1[C:6]2([CH2:11][CH2:10][N:9](C(OCC3C=CC=CC=3)=O)[CH2:8][CH2:7]2)[CH2:5][O:4][C:3]1([CH3:23])[CH3:22]>CO.[Pd]>[OH:1][CH:2]1[C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][O:4][C:3]1([CH3:23])[CH3:22]

참가 물질

4

반응물 1

HCID 69148474HCID 69148474, 화합물

생성물 1

HCID 691473354-Hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Benzyl 4-hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylate (from step (iii) above; 180 mg) was dissolved in methanol and palladium on carbon (5%) was added. The mixture was hydrogenated at atmospheric pressure for 30 min. The catalyst was removed by filtration through Hyflo™ and the solvent was evaporated in vacuo to afford the product as a white solid.

후처리

  1. customThe catalyst was removed by filtration through Hyflo™
  2. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-500f7eb397384da2983159cada5dfeec
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07393858B2

반응 노트

불러오는 중…