Guanidine Hydrochloride → 4-(2-Furyl)pyrimidin-2-amine
반응식
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[O:8][CH:9]=[CH:10][CH:11]=1)=O.Cl.[NH2:14][C:15]([NH2:17])=[NH:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[CH:4]=[CH:3][N:14]=[C:15]([NH2:17])[N:16]=1참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
A suspension of 3-(dimethylamino)-1-(2-furyl)-2-propen-1-one (5.0 g, 30.3 mmol), guanidine hydrochloride (5.8 g, 60.7 mmol) and potassium carbonate (8.4 g, 60.9 mmol) in N,N-dimethylformamide (50 ml) was stirred at 100° C. for 21 hours. After cooling as it was, the reaction mixture was diluted with ice water (250 ml). The resulting solid was collected by filtration and washed with water, to give the title compound (4.19 g, 86%) as a pale brown solid.
후처리
- temperatureAfter cooling as it
- filtrationThe resulting solid was collected by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-ba7a7b4ac8394a0d8d1decdb2490eafb
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07396836B2
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