Allyl Alcohol → [3-(5-Bromothien-2-yl)-4,5-dihydroisoxazol-5-yl]methanol

HRID 747196노트

반응식

HRID 747196 반응식
[Br:1][C:2]1[S:6][C:5]([CH:7]=[N:8][OH:9])=[CH:4][CH:3]=1.[CH2:10]([OH:13])[CH:11]=[CH2:12]>O1CCCC1>[Br:1][C:2]1[S:6][C:5]([C:7]2[CH2:12][CH:11]([CH2:10][OH:13])[O:9][N:8]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 7858Allyl AlcoholHCID 200491N-[(5-bromothiophen-2-yl)methylidene]hydroxylamine

생성물 1

HCID 17954475[3-(5-Bromothien-2-yl)-4,5-dihydroisoxazol-5-yl]methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5-Bromo-thiophene-2-carbaldehyde oxime (40.2 g, 195.2 mmol) and allyl alcohol (32.4 ml) were added to tetrahydrofuran (200 ml) and then bleach (1318 ml) was added. The reaction was stirred for four hours followed by extraction with tetrahydrofuran (2×200 ml). The organic layers were combined, dried over sodium sulfate, and concentrated in vacuo to give the desired product (19 g).

후처리

  1. additionwas added
  2. extractionfollowed by extraction with tetrahydrofuran (2×200 ml)
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-559ae188f9b84d10bd02bb3c32e997cc
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396847B2

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