Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(3-Methylpyridin-2-yl)methanol → 3-Methylpyridine-2-carboxaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (3-Methylpyridin-2-yl)methanol | HCID 1514369 | — |
| 촉매 | Manganese dioxide | HCID 14801 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Methylpyridine-2-carboxaldehyde | HCID 1501874 | 64% |
반응 단계
To a stirred solution of 2-(hydroxymethyl)-3-methylpyridine (1.08 g, 8.77 mmol) in dry CH2Cl2 (45 mL) at room temperature was added MnO2 (8.09 g, 79.1 mmol). The mixture was stirred for 21 hrs then filtered through celite. The filtrate was concentrated to give 0.68 g (64%) of 3-methylpyridine-2-carboxaldehyde. 1H NMR (CDCl3) □ 2.66 (s, 3H), 7.39 (dd, 1H, J=8.3, 4.3 Hz), 7.63 (d, 1H, J=7.9 Hz), 8.66 (d, 1H, J=3.3 Hz), 10.19 (s, 1H). This was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07396840B2 |
| 출처 데이터셋 | uspto-grants-2008_07 |
| ORD ID | ord-79276cd25702424f90854d58f89435ed |
| 출처 메모 | uspto-grants-2008_07 |