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2-Bromoacetamide → N2-{4-chloro-2-[hydroxy(3-methoxyphenyl)methyl]phenyl}-N2-[(3,4-dimethoxyphenyl)sulfonyl]glycinamide

HRID 747601
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인쇄 미리보기

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HRID 747601 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)(=[O:11])=[O:10])=[C:4]([CH:22]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=2)[OH:23])[CH:3]=1.CC(C)([O-])C.[K+].Br[CH2:39][C:40]([NH2:42])=[O:41]>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([S:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)(=[O:11])=[O:10])[CH2:39][C:40]([NH2:42])=[O:41])=[C:4]([CH:22]([OH:23])[C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=2)[CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 696322-BromoacetamideHCID 23665647Potassium tert-butoxideHCID 68567514N-{4-chloro-2-[(3-methoxyphenyl)(hydroxy)methyl]phenyl}-3,4-dimethoxybenzenesulfonamide

생성물 1

HCID 58941201N2-{4-chloro-2-[hydroxy(3-methoxyphenyl)methyl]phenyl}-N2-[(3,4-dimethoxyphenyl)sulfonyl]glycinamide수율 50.9%

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

To 0.7 g of N-{4-chloro-2-[(3-methoxyphenyl)(hydroxy)methyl]phenyl}-3,4-dimethoxybenzenesulfonamide dissolved in 5 ml of THF are added, at room temperature, 0.2 g of potassium tert-butoxide and 0.25 g of 2-bromoacetamide. After 48 hours at 20° C., the reaction medium is concentrated, taken up in ethyl acetate and washed with water. The organic phase is dried over anhydrous sodium sulfate and concentrated. The residue is chromatographed on a column of silica gel, eluting with dichloromethane to give 0.4 g of the expected product.

후처리

  1. additionare added, at room temperature
  2. concentrationthe reaction medium is concentrated
  3. washwashed with water
  4. dry with materialThe organic phase is dried over anhydrous sodium sulfate
  5. concentrationconcentrated
  6. customThe residue is chromatographed on a column of silica gel
  7. washeluting with dichloromethane

출처 및 근거

ORD 기록
ord-16c6800fec944a298707f4be9b5e2efc
출처 데이터셋
uspto-grants-2008_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07396958B2

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