Ammonia → N-[2-(3-cyanophenoxy)ethyl]-4-carbamoylbenzamide

HRID 747663노트

반응식

HRID 747663 반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:22]=[CH:23][CH:24]=1)[O:6][CH2:7][CH2:8][NH:9][C:10]([C:12]1[CH:21]=[CH:20][C:15]([C:16](OC)=[O:17])=[CH:14][CH:13]=1)=[O:11])#[N:2].[NH3:25]>>[C:1]([C:3]1[CH:4]=[C:5]([CH:22]=[CH:23][CH:24]=1)[O:6][CH2:7][CH2:8][NH:9][C:10](=[O:11])[C:12]1[CH:21]=[CH:20][C:15]([C:16](=[O:17])[NH2:25])=[CH:14][CH:13]=1)#[N:2]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 68830761methyl 4-[N-[2-(3-cyanophenoxy)ethyl)carbamoyl]benzoate

생성물 1

HCID 68835528N-[2-(3-cyanophenoxy)ethyl]-4-carbamoylbenzamide

실험 절차

100 mg (0.31 mmol) of methyl 4-[N-[2-(3-cyanophenoxy)ethyl)carbamoyl]benzoate was stirred in 100 ml of 28% aqueous ammonia overnight. The reaction liquid was evaporated under reduced pressure, and 1 N hydrochloric acid was added to the residue. After the extraction with ethyl acetate, the organic layer was washed with saturated aqueous NaCl solution and then dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the title compound.

후처리

  1. customThe reaction liquid
  2. customwas evaporated under reduced pressure, and 1 N hydrochloric acid
  3. additionwas added to the residue
  4. extractionAfter the extraction with ethyl acetate
  5. washthe organic layer was washed with saturated aqueous NaCl solution
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-8fb0f1d5eebf44a795ebaed067c60749
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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