Dimethylamine → ethyl 4-(N,N-dimethylamidino)benzoate

HRID 747670

반응식

HRID 747670 반응식
Cl.C(O[C:5]([C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=1)=[NH:6])C.[CH3:18][NH:19][CH3:20]>C(O)C>[CH3:18][N:19]([CH3:20])[C:5]([C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=1)=[NH:6]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 68830640Ethyl 4-ethoxycarbonimidoylbenzoate hydrochloride

생성물 1

HCID 22631319ethyl 4-(N,N-dimethylamidino)benzoate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1 g (3.9 mmol) of ethyl 4-ethoxycarbonimidoylbenzoate hydrochloride was stirred in a mixture of 3 ml of ethanol and 10 ml of 50% aqueous dimethylamine solution overnight. Then the solvent was evaporated, and 10 ml of dioxane containing 4 N hydrogen chloride and 1 ml of ethanol were added to the residue. After stirring at room temperature for 5 days, the solvent was evaporated. 1 N sodium hydroxide was added to the residue. After the extraction with dichloromethane, the organic layer was washed with saturated Aqueous NaCl solution and dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the title compound.

후처리

  1. customThen the solvent was evaporated
  2. addition10 ml of dioxane containing 4 N hydrogen chloride and 1 ml of ethanol were added to the residue
  3. customthe solvent was evaporated
  4. addition1 N sodium hydroxide was added to the residue
  5. extractionAfter the extraction with dichloromethane
  6. washthe organic layer was washed with saturated Aqueous NaCl solution
  7. dry with materialdried over anhydrous magnesium sulfate
  8. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-0cc42a4a09e1470db033722a0a9aeb69
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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