Potassium Iodide → HCID 68829534, 화합물

HRID 747776노트

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HRID 747776 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:23][CH2:24][O:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=1)[C:29]#[N:30].[I-].[K+].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21][CH2:23][CH2:24][O:25][C:26]3[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=3)[C:29]#[N:30])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 177889413-(2-bromoethoxy)benzonitrileHCID 22181157tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

생성물 1

HCID 68829534HCID 68829534, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

616 mg (1.91 mmol) of 1-t-butoxycarbonyl-4-(4-aminophenoxy)piperidine, 432 ml (1.91 mmol) of 3-(2-bromoethoxy)benzonitrile and 634 mg (3.82 mmol) of potassium iodide were dissolved in 20 ml of dimethylformamide. 2.64 g (19.1 mmol) of potassium carbonate was added to the solution, and they were stirred at room temperature for 14 hours. The solvent was distilled off under reduced pressure. After the treatment with ethyl acetate as extractant in an ordinary manner, the crude product was obtained. This product was purified by the silica gel column chromatography to obtain the title compound.

후처리

  1. distillationThe solvent was distilled off under reduced pressure
  2. customAfter the treatment with ethyl acetate as extractant in an ordinary manner, the crude product was obtained
  3. customThis product was purified by the silica gel column chromatography

출처 및 근거

ORD 기록
ord-21442828d21b4c33bd0871afa108cb0f
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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