Dimethylformamide → 1-(Pyridine-4-yl)-piperidine-4-carboxylate chloride
반응식
Cl.[N:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.CN(C)C=O.C(Cl)(=O)C([Cl:25])=O>ClCCl>[Cl-:25].[N:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([O-:16])=[O:15])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1참가 물질
5
실험 절차
7 g (34 mmol) of 1-(pyridine-4-yl)-piperidine-4-carboxylate hydrochloride was stirred in 340 ml of dichloromethane, and 1 ml of dimethylformamide and 10.4 ml (109 mmol) of oxalyl dichloride were added thereto and stirred at room temperature for 1 hour. The solvent was distilled off, and the residue was dried with a vacuum pump to obtain the title compound.
후처리
- distillationThe solvent was distilled off
- customthe residue was dried with a vacuum pump
출처 및 근거
- ORD 기록
- ord-2197a7a9cfe3418495ac5a2a708a9c04
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07396844B1
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