Potassium Iodide → HCID 68836373, 화합물

HRID 747789노트

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HRID 747789 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13]Cl)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[C:19]#[N:20].[I-].[K+].C(=O)([O-])[O-].[K+].[K+]>C[N-]C.C(OCC)(=O)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13][O:15][C:16]1[CH:23]=[CH:22][CH:21]=[C:18]([C:19]#[N:20])[CH:17]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

7

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 133943-CyanophenolHCID 54012228tert-Butyl (2R)-2-(chloromethyl)pyrrolidine-1-carboxylate

생성물 1

HCID 68836373HCID 68836373, 화합물

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 182180Dimethylazanide용매

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온도
90 °C

실험 절차

430 mg (2 mmol) of 1-t-butoxycarbonyl-(2R)-2-chloromethyl pyrrolidine was dissolved in 5 ml of dimethylamide, and 238 mg (2 mmol) of 3-hydroxy benzonitrile, 500 mg (3 mmol) of potassium iodide, and 414 mg (3 mmol) of potassium carbonate were added thereto and stirred at 90° C. for 3 days. The reaction mixture was treated in an ordinary manner with ethyl acetate as the extractant, and the resulting residue was purified by silica gel column chromatography to obtain the title compound.

후처리

  1. customwas purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-5319edb120b142f98aa8b1fa45921010
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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