Potassium Carbonate → 4-(1-Oxo-indan-5-yloxy)-benzonitrile

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-Fluorobenzonitrile	HCID 14517	—
반응물	5-Hydroxy-1-indanone	HCID 233147	—
반응물	toluene N,N-dimethylacetamide	HCID 66603805	—
용매	Ethyl Acetate	HCID 8857	—
생성물	4-(1-Oxo-indan-5-yloxy)-benzonitrile	HCID 59750643	51.3%

반응 단계

Combine 5-Hydroxyindanone (2.0 g, 13.50 mmol), 4-Fluorobenzonitrile (1.55 g, 12.80 mmol), K2CO3 (2.65 g, 19.20 mmol) and toluene/DMA (20 ml/40 ml), reflux under Nitrogen using a Dean-Stark Trap. After 4.0 hours, cool the reaction to room temperature and add Ethyl Acetate. Wash several times with 10% LiCl and Brine solution, then dry the organic layer over Na2SO4 follow by concentration. Flash chromatograph using 4/1 then 1/1 hexanes/ethyl acetate eluant to afford 1.64 g, 6.57 mmol (49% yield) of the title compound: 1H NMR (500 MHz, CDCl3); 2.7-2.8 (2H, m), 3.1-3.2 (2H, m), 7.0-7.1 (2H, m), 7.1-7.2 (2H, m), 7.6-7.7 (2H, m), 7.7-7.8 (1H, m); MS m/z 250 (M+1).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07399774B2
출처 데이터셋	uspto-grants-2008_07
ORD ID	ord-b6f0d1d89b4a4e5d83b20bef39093f66
출처 메모	uspto-grants-2008_07