Methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoate → 2-[3-[2-(3-Fluorophenyl)-5-methyloxazol-4-ylmethoxy]cyclohexyloxymethyl]-6-methylbenzoic Acid

HRID 748016

반응식

HRID 748016 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([O:8][CH2:9][C:10]2[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:11]=2[C:12]([O:14]C)=[O:13])[CH2:3]1.[F:21][C:22]1[CH:23]=[C:24]([C:28]2[O:29][C:30]([CH3:35])=[C:31]([CH2:33]I)[N:32]=2)[CH:25]=[CH:26][CH:27]=1>>[F:21][C:22]1[CH:23]=[C:24]([C:28]2[O:29][C:30]([CH3:35])=[C:31]([CH2:33][O:1][CH:2]3[CH2:7][CH2:6][CH2:5][CH:4]([O:8][CH2:9][C:10]4[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:11]=4[C:12]([OH:14])=[O:13])[CH2:3]3)[N:32]=2)[CH:25]=[CH:26][CH:27]=1

참가 물질

3

반응물 2

HCID 21980299Methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoateHCID 224936892-(3-Fluorophenyl)-4-iodomethyl-5-methyloxazole

생성물 1

HCID 224936832-[3-[2-(3-Fluorophenyl)-5-methyloxazol-4-ylmethoxy]cyclohexyloxymethyl]-6-methylbenzoic Acid

실험 절차

Using methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoate and 2-(3-fluorophenyl)-4-iodomethyl-5-methyloxazole as starting materials in the procedure of Example XXXI, gave the product 52 of molecular weight 453.52 (C26H28FNO5), MS(ESI): 454.35 (M+H+).

출처 및 근거

ORD 기록
ord-60de564420cf4abcb4ea4acf1d93d840
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07399777B2

연결된 노트

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