1H-1,2,4-Triazole → 1-(4-Methoxybenzyl)-1,2,4-triazole

HRID 748061노트

반응식

HRID 748061 반응식
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[CH3:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12]Cl)=[CH:10][CH:9]=1.C1CCN2C(=NCCC2)CC1>C1COCC1>[CH3:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 92571H-1,2,4-TriazoleHCID 699934-Methyloxybenzyl chlorideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

생성물 1

HCID 108453281-(4-Methoxybenzyl)-1,2,4-triazole수율 57%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 1,2,4-triazole (2.0 g, 29 mmol) in THF (80 mL) at 0° C. was added 4-methoxybenzyl chloride (4.0 mL, 29 mmol) and DBU (5.20 mL, 34.7 mmol). The reaction mixture was warmed to room temperature and allowed to stir overnight. The solution was filtered and the filtrate was concentrated. The resulting residue was purified by column chromatography (EtOAc/MeOH, 1:9) to give 3.12 g (57%) of 1-(4-methoxybenzyl)-1H-1,2,4-triazole as a colorless oil.

후처리

  1. filtrationThe solution was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe resulting residue was purified by column chromatography (EtOAc/MeOH, 1:9)

출처 및 근거

ORD 기록
ord-ad67110a16d7408c8de6eff2bf355f35
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07399778B2

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