Triethylamine → 2-(1H-Pyrrol-2-yl)-4H-1,3-benzothiazine-4-one
반응식
[C:1]([O:10]C)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[SH:4].[NH:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]#[N:18].C(N(CC)CC)C>C1(C)C=CC=CC=1>[NH:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]1[S:4][C:3]2[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=2[C:1](=[O:10])[N:18]=1참가 물질
5
실험 절차
A mixture of methyl thiosalicylate (2.00 g, 11.8 mmol), pyrrole-2-carbonitrile (1.10 g, 11.9 mmol), triethylamine (2.00 ml, 14.3 mmol) and toluene (4.0 ml) was refluxed for 15 hrs as described in Example 1. After cooling, the precipitated crystals were collected by filtration and recrystallized from hexane-ethanol to give the titled compound (1.90 g, 73%).
후처리
- temperaturewas refluxed for 15 hrs
- temperatureAfter cooling
- filtrationthe precipitated crystals were collected by filtration
- customrecrystallized from hexane-ethanol
출처 및 근거
- ORD 기록
- ord-914c2e6c0092441c84ca02b96262e710
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07399759B2
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