Trifluoroacetic acid → methyl (2S)-2-amino-3-(quinolin-6-yl)propanoate
반응식
[CH3:1][O:2][C:3]1[C@H:4]([CH2:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[N:21]=[CH:20][CH:19]=[CH:18]3)[N:5]=C(OC)[C@@H](C(C)C)N=1.FC(F)(F)C(O)=[O:28]>O.C(#N)C>[NH2:5][C@@H:4]([CH2:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[N:21]=[CH:20][CH:19]=[CH:18]2)[C:3]([O:2][CH3:1])=[O:28]참가 물질
5
반응 조건
- 온도
- 10 °C
실험 절차
To a solution of #211 (7.3 g, 22.5 mmol, 1 eq.) in water (25 mL) and acetonitrile (80 mL) was added trifluoroacetic acid (9 mL) at 0° C. and the solution was stirred at 10° C. overnight. The organic layer was removed in vacuo and the remaining aqueous layer was basified to pH 9 with sodium carbonate, which was directly used for the next step.
후처리
- customThe organic layer was removed in vacuo
출처 및 근거
- ORD 기록
- ord-4a9bf0aebfb24ab29f3d2c36f70c87d7
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08828401B2
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