m-Chloroperbenzoic acid → 2-(3-Oxo-3-tert-butoxy-1-propenyl)pyridine 1-oxide
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1/[CH:7]=[CH:8]/[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10].ClC1C=CC=C(C(OO)=[O:24])C=1>C(OCC)(=O)C>[O-:24][N+:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1/[CH:7]=[CH:8]/[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]참가 물질
4
실험 절차
tert-Butyl (E)-3-(2-pyridyl)-2-propenoate (2.05 g, 10.0 mmol) was dissolved in ethyl acetate (10 ml), and 3-chloroperbenzoic acid (ca. 70%, 2.35 g, 10.5 mmol) was added thereto. The mixture was stirred at room temperature overnight. The reaction mixture was subjected to a silica gel (100 g) column chromatography. The fractions eluted with ethyl acetate-ethanol (5:1, v/v) were collected and concentrated to give the title compound (2.14 g, 96%).
후처리
- washThe fractions eluted with ethyl acetate-ethanol (5:1
- customv/v) were collected
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-ebce91a7cbe24447a43591eb488222ba
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07399759B2
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