Trifluoroacetic acid → 3-[6-(7-Methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid

HRID 748239노트

반응식

HRID 748239 반응식
[CH3:1][O:2][C:3]1[CH:28]=[CH:27][C:6]2[C:7](=[O:26])[N:8]=[C:9]([C:11]3[N:16]=[C:15]([CH2:17][CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[CH:14]=[CH:13][CH:12]=3)[S:10][C:5]=2[CH:4]=1.FC(F)(F)C(O)=O>>[CH3:1][O:2][C:3]1[CH:28]=[CH:27][C:6]2[C:7](=[O:26])[N:8]=[C:9]([C:11]3[N:16]=[C:15]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:14]=[CH:13][CH:12]=3)[S:10][C:5]=2[CH:4]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 22939580tert-Butyl 3-[6-(7-methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate

생성물 1

HCID 597501523-[6-(7-Methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid

반응 조건

온도
0 °C

실험 절차

A mixture of tert-butyl 3-[6-(7-methoxy-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate (0.40 g, 1.0 mmol) obtained in Example 173 and trifluoroacetic acid (5.0 ml) was stirred at 0° C. for 2 hrs. The reaction mixture was concentrated under reduced pressure, combined with diisopropyl ether to give the crystals, which were collected by filtration and dried.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto give the crystals, which
  3. filtrationwere collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-ab1b46ece9e947a493bd4a0d9fe126e9
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07399759B2

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