Trifluoroacetic acid → 3-[6-(7-Methyl-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid

HRID 748241노트

반응식

HRID 748241 반응식
[CH3:1][C:2]1[CH:27]=[CH:26][C:5]2[C:6](=[O:25])[N:7]=[C:8]([C:10]3[N:15]=[C:14]([CH2:16][CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])[CH:13]=[CH:12][CH:11]=3)[S:9][C:4]=2[CH:3]=1.FC(F)(F)C(O)=O>>[CH3:1][C:2]1[CH:27]=[CH:26][C:5]2[C:6](=[O:25])[N:7]=[C:8]([C:10]3[N:15]=[C:14]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[CH:13]=[CH:12][CH:11]=3)[S:9][C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 22939357HCID 22939357, 화합물

생성물 1

HCID 597504403-[6-(7-Methyl-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid수율 101.1%

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온도
0 °C

실험 절차

A mixture of tert-butyl 3-[6-(7-methyl-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate (0.40 g, 1.0 mmol) obtained in Example 175 and trifluoroacetic acid (5.0 ml) was stirred at 0° C. for 2 hrs. The reaction mixture was concentrated under reduced pressure and combined with diisopropyl ether to precipitate crystals, which were collected by filtration and dried to give the titled compound (0.33 g, 97%).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto precipitate crystals, which
  3. filtrationwere collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-ef80994abf184cf6b11a27ea2f7a87d6
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07399759B2

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