m-Chloroperbenzoic acid → 2-(1,3-Oxazol-5-yl)pyridine N-oxide

HRID 748271노트

반응식

HRID 748271 반응식
[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=2)=[CH:4][N:3]=[CH:2]1.ClC1C=CC=C(C(OO)=[O:20])C=1>C(OCC)(=O)C>[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][N+:7]=2[O-:20])=[CH:4][N:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 7371945-(2-Pyridyl)oxazole

생성물 1

HCID 597502552-(1,3-Oxazol-5-yl)pyridine N-oxide수율 35.7%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

2-(1,3-Oxazol-5-yl)pyridine (2.8 g, 19 mmol) and 3-chloroperbenzoic acid (77%, 13.6 g, 58 mmol) were dissolved in ethyl acetate, and the mixture was stirred at room temperature for 6 days. The solvent was evaporated, and the residue was subjected to a silica gel column chromatography. The fractions eluted with methanol-ethyl acetate (1:4, v/v) were collected and concentrated to give the titled compound (1.1 g, 34%).

후처리

  1. customThe solvent was evaporated
  2. washThe fractions eluted with methanol-ethyl acetate (1:4, v/v)
  3. customwere collected
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ac5f5042ae87418e9c1367754b13ba5d
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07399759B2

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