Triethylamine → 2-(1,3-thiazol-2-yl)-4H-1,3-benzothiazin-4-one
반응식
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]#[N:7].[C:8](OC)(=[O:16])[C:9]1[C:10](=[CH:12][CH:13]=[CH:14][CH:15]=1)[SH:11].C(N(CC)CC)C>C1(C)C=CC=CC=1>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[S:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[C:8](=[O:16])[N:7]=1참가 물질
5
실험 절차
1,3-Thiazole-2-carbonitrile (0.32 g, 2.9 mmol) and methyl thiosalicylate (0.98 g, 5.8 mmol) were dissolved in toluene (4 ml), and triethylamine (2.0 ml, 14.3 mmol) was added thereto. The reaction mixture was refluxed for 2 hrs. After cooling, the precipitates were collected by filtration and recrystallized from diisopropyl ether-ethanol to give the titled compound (0.51 g, 70%) as yellow crystals.
후처리
- temperatureThe reaction mixture was refluxed for 2 hrs
- temperatureAfter cooling
- filtrationthe precipitates were collected by filtration
- customrecrystallized from diisopropyl ether-ethanol
출처 및 근거
- ORD 기록
- ord-1a9e12e4546f4710b7ed182e904ca15e
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07399759B2
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