Methanol → 5-Bromo-2-methanesulfonyl-1,3-dimethyl-benzene

HRID 748966노트

반응식

HRID 748966 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH3:11])[C:5](SC)=[C:6]([CH3:8])[CH:7]=1.O[O:13][S:14]([O-:16])=O.[K+].[CH3:18]O>>[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([S:14]([CH3:18])(=[O:16])=[O:13])=[C:4]([CH3:11])[CH:3]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 23707502Potassium hydroxy sulfiteHCID 685195015-Bromo-1,3-dimethyl-2-(methylsulfanyl)benzene

생성물 1

HCID 685159425-Bromo-2-methanesulfonyl-1,3-dimethyl-benzene수율 50%

실험 절차

Dissolve 5-bromo-1,3-dimethyl-2-methylsulfanyl-benzene (555 mg, 2.42 mmol) in methanol (30 mL) and treat with oxone (6.0 g, 9.8 mmol). Stir the mixture at ambient temperature for 1 hour. Filter the suspension through silica gel and elute with CH2Cl2 (100 mL). Evaporate the filtrate to give 316 mg (50%) of the title compound.

후처리

  1. filtrationFilter the suspension through silica gel
  2. washelute with CH2Cl2 (100 mL)
  3. customEvaporate the filtrate

출처 및 근거

ORD 기록
ord-2753041af57f42b499dfb3b76317b685
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07399867B2

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