Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 7490생성일: 2026년 10월 23일
Hydrochloric Acid → 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[(1-methylimidazol-2-yl)methoxy]cinnoline hydrochloride
https://huagongshe.com/ko/reaction/7490
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | 5-Amino-4-fluoro-2-methylphenol | HCID 10154098 | — |
| 반응물 | 4-Chloro-6-methoxy-7-[(1-methylimidazol-2-yl)methoxy]cinnoline | HCID 21991019 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | 2-Pentanol | HCID 22386 | — |
| 생성물 | 4-(2-Fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[(1-methylimidazol-2-yl)methoxy]cinnoline hydrochloride | HCID 21991024 | 79.5% |
반응 단계
A suspension of 4-chloro-6-methoxy-7-[( 1-methylimidazol-2-yl)methoxy]cinnoline (109 mg, 0.35 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (70 mg, 0.5 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (3 ml), DMF (0.5 ml) and a 5M solution of hydrogen chloride in isopropanol (74 μl, 0.35 mmol) was heated at reflux for 3 hours. The solution was then cooled to 0° C. and the resulting solid filtered off and washed with ether to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[(1-methylimidazol-2-yl)methoxy]cinnoline hydrochloride as a yellow solid (124 mg, 73%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07087602B2 |
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| 출처 데이터셋 | uspto-grants-2006_08 |
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| ORD ID | ord-1ef1353ef9b0448aa2e55a73c9130f30 |
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| 출처 메모 | uspto-grants-2006_08 |
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