Thioanisole → 4-(4-(2-Methoxyphenoxy)-anilino)-3-cyano-6-methoxy-7-hydroxyquinoline

HRID 749059노트

반응식

HRID 749059 반응식
[CH3:1][O:2][C:3]1[CH:38]=[CH:37][CH:36]=[CH:35][C:4]=1[O:5][C:6]1[CH:34]=[CH:33][C:9]([NH:10][C:11]2[C:20]3[C:15](=[CH:16][C:17]([O:23]CC4C=CC=CC=4)=[C:18]([O:21][CH3:22])[CH:19]=3)[N:14]=[CH:13][C:12]=2[C:31]#[N:32])=[CH:8][CH:7]=1.C1(SC)C=CC=CC=1>FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]1[CH:38]=[CH:37][CH:36]=[CH:35][C:4]=1[O:5][C:6]1[CH:34]=[CH:33][C:9]([NH:10][C:11]2[C:20]3[C:15](=[CH:16][C:17]([OH:23])=[C:18]([O:21][CH3:22])[CH:19]=3)[N:14]=[CH:13][C:12]=2[C:31]#[N:32])=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 7520ThioanisoleHCID 98274294-(4-(2-Methoxyphenoxy)-anilino)-3-cyano-6-methoxy-7-(benzyloxy)quinoline

생성물 1

HCID 1358198314-(4-(2-Methoxyphenoxy)-anilino)-3-cyano-6-methoxy-7-hydroxyquinoline

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매2회

실험 절차

The product from step (1) (7.2 g, 14.3 mmole) trifluoroacetic acid (40 ml) and thioanisole (8.38 ml, 71.5 mmole) was refluxed in a nitrogen atmosphere for 3 hours. After cooling the trifluoroacetic acid was removed by rotary evaporation and the oily residue was stirred with ice and water and basified with aqueous ammonia (S.G. 0.880). The resulting suspension was filtered and the solid was washed successively with water, ethyl acetate and diethyl ether and then dried to give 4-(4-(2-methoxyphenoxy)-anilino)-3-cyano-6-methoxy-7-hydroxyquinoline.

후처리

  1. customwas removed by rotary evaporation
  2. filtrationThe resulting suspension was filtered
  3. washthe solid was washed successively with water, ethyl acetate and diethyl ether
  4. customdried

출처 및 근거

ORD 기록
ord-73a06a556c304014a2b5668ca39ac412
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402583B2

반응 노트

불러오는 중…