Toluene → 2-Bromo-1-(4-(2-methylpropyl)phenyl)ethan-1-one

HRID 749225

반응식

HRID 749225 반응식
[Br:1]Br.[CH2:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][CH:8]=1)[CH:4]([CH3:6])[CH3:5].C1(C)C=CC=CC=1>C(O)C>[Br:1][CH2:14][C:13]([C:10]1[CH:9]=[CH:8][C:7]([CH2:3][CH:4]([CH3:6])[CH3:5])=[CH:12][CH:11]=1)=[O:15]

참가 물질

5

반응물 3

HCID 1140TolueneHCID 24408BromineHCID 932144'-Isobutylacetophenone

생성물 1

HCID 136563372-Bromo-1-(4-(2-methylpropyl)phenyl)ethan-1-one수율 57%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
5 °C

실험 절차

Bromine (1.25 ml; 25 mmol) is added dropwise to a solution of 4′-isobutylacetophenone (3.52 g; 20 mmol) in 60 ml of ethanol cooled down to approximately 5° C. After stirring the reaction mixture for 30 minutes at this temperature, stirring is continued for one hour at ambient temperature. The reaction medium, to which small portions of toluene are added, is concentrated to dryness. After purification on a silica column (eluent: ethyl-heptane acetate: 5-95), a colourless oil is obtained with a yield of 57%.

후처리

  1. stirringstirring
  2. waitis continued for one hour at ambient temperature
  3. concentrationis concentrated to dryness
  4. customAfter purification on a silica column (eluent: ethyl-heptane acetate: 5-95)
  5. customa colourless oil is obtained with a yield of 57%

출처 및 근거

ORD 기록
ord-37cffd1cac174c97ae12e2ea559231b3
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402602B2

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