Pyridinium chloride → 7-Acetyl-4-hydroxybenzo[d]thiazol-2(3H)-one
반응식
[C:1]([C:4]1[C:12]2[S:11][C:10](=[O:13])[NH:9][C:8]=2[C:7]([O:14]C)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].Cl.N1C=CC=CC=1>CN1CCCC1=O.O>[C:1]([C:4]1[C:12]2[S:11][C:10](=[O:13])[NH:9][C:8]=2[C:7]([OH:14])=[CH:6][CH:5]=1)(=[O:3])[CH3:2]참가 물질
5
실험 절차
A mixture of 7-acetyl4-methoxy-1,3-benzothiazol-2(3H)-one (1.2 g), pyridine hydrochloride (2.77 g), in dry 1-methyl-2-pyrrolidone(6 ml), was heated at 190° C. in a microwave reactor for 90 min. The reaction mixture was cooled to room temperature, and diluted with water. The precipitated solid was collected by filtration, washed with water and dried under vacuum at 40° C. to give the title compound (1.07 g). LCMS RT=2.46 min.
후처리
- filtrationThe precipitated solid was collected by filtration
- washwashed with water
- customdried under vacuum at 40° C.
출처 및 근거
- ORD 기록
- ord-fe87213bfd7e406bb29aebc33ee06b8e
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07402598B2
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