Methyl N-[(1R,3S)-3-benzyloxycarbonylaminocyclohexyl]carbamate → methyl N-[(1R,3S)-3-aminocyclohexyl]carbamate

HRID 74924노트

반응식

HRID 74924 반응식
[CH2:1]([O:8][C:9]([NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][C@@H:14]([NH:18]C(=O)OC)[CH2:13]1)=[O:10])C1C=CC=CC=1.C(OC([C@H]1CCC[C@@](N)(NC(=O)OC)C1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:18][C@H:14]1[CH2:15][CH2:16][CH2:17][C@@H:12]([NH:11][C:9](=[O:10])[O:8][CH3:1])[CH2:13]1

참가 물질

5

반응물 2

HCID 68007620Methyl N-[(1R,3S)-3-benzyloxycarbonylaminocyclohexyl]carbamateHCID 68007622methyl N-[(1R,3S)-3-benzyloxycarbonyl-aminocyclohexyl]carbamate

생성물 1

HCID 68007555methyl N-[(1R,3S)-3-aminocyclohexyl]carbamate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Methyl N-[(1R,3S)-3-benzyloxycarbonylaminocyclohexyl]carbamate, 19a, (1.09 g, 3.56 mmol) was dissolved in ethanol (100 mL) and treated with 10% Pd/C (0.38 g, 0.36 mmol). The flask was capped, degassed and fitted with a hydrogen balloon and allowed to stir overnight. The reaction mixture was filtered under nitrogen and concentrated in vacuo to provide the product, 19b, as a white solid.

후처리

  1. customThe flask was capped
  2. customdegassed
  3. customfitted with a hydrogen balloon
  4. filtrationThe reaction mixture was filtered under nitrogen
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-496dd94c47ba4f1da0500bcbc8bd66d5
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829007B2

반응 노트

불러오는 중…