(2-Azido-3-fluoro-propyl)benzene → 1-Fluoro-3-phenylpropan-2-amine

HRID 749299노트

반응식

HRID 749299 반응식
[N:1]([CH:4]([CH2:12][F:13])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[N+]=[N-]>CO.[Pd]>[F:13][CH2:12][CH:4]([NH2:1])[CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

참가 물질

4

반응물 1

HCID 22054864(2-Azido-3-fluoro-propyl)benzene

생성물 1

HCID 50645991-Fluoro-3-phenylpropan-2-amine수율 74.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매2회

실험 절차

To a solution of (2-azido-3-fluoro-propyl)benzene (0.6 g) in MeOH (50 mL) was added 10% Pd/C catalyst and the suspension was hydrogenated for 2 hr. at 3 atmospheres pressure. The filtered reaction mixture and MeOH washings were concentrated to an oil which was chromatographed over silica gel with an ammoniated mixture of MeOH/ether (1:9) to give 0.38 g of the title compound. MS ES (M++H)=154.

후처리

  1. concentrationwere concentrated to an oil which
  2. customwas chromatographed over silica gel with an ammoniated mixture of MeOH/ether (1:9)

출처 및 근거

ORD 기록
ord-98fe17384f7148449a9ea79d8deada1b
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402604B2

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