Cesium carbonate → 2-(4-Chlorobenzyl)-2-(2,2,3,3-tetrafluoropropyl)malononitrile

HRID 749538

반응식

HRID 749538 반응식
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][CH:7]([C:10]#[N:11])[C:8]#[N:9])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].FC(F)(F)S(O[CH2:26][C:27]([F:32])([F:31])[CH:28]([F:30])[F:29])(=O)=O>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]([CH2:26][C:27]([F:32])([F:31])[CH:28]([F:30])[F:29])([C:8]#[N:9])[C:10]#[N:11])=[CH:12][CH:13]=1

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 180822-((4-Chlorophenyl)methyl)propanedinitrileHCID 37924752,2,3,3-Tetrafluoropropyl trifluoromethanesulfonate

생성물 1

HCID 222349962-(4-Chlorobenzyl)-2-(2,2,3,3-tetrafluoropropyl)malononitrile수율 7.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using 1.0 g of (4-chlorobenzyl)malononitrile, 15 ml of N,N-dimethylformamide, 0.073 g of cesium carbonate, and 1.47 g of 2,2,3,3-tetrafluoropropyl trifluoromethanesulfonate, and according to the process described in the Production Example 1, there was obtained 0.12 g of 2-(4-chlorobenzyl)-2-(2,2,3,3-tetrafluoropropyl)malononitrile (the present compound (25)).

출처 및 근거

ORD 기록
ord-d49ce21b57264ee3b0098b5e4a962e0e
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402691B2

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