4-(Trifluoromethoxy)benzalmalononitrile → HCID 22235037, 화합물

HRID 749603노트

반응식

HRID 749603 반응식
[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:15]=[CH:14][C:7]([CH:8]=[C:9]([C:12]#[N:13])[C:10]#[N:11])=[CH:6][CH:5]=1.[CH3:18][Mg]Br>O1CCCC1.[Cu]I>[F:1][C:2]([F:16])([F:17])[O:3][C:4]1[CH:5]=[CH:6][C:7]([CH:8]([CH:9]([C:12]#[N:13])[C:10]#[N:11])[CH3:18])=[CH:14][CH:15]=1

참가 물질

5

반응물 2

HCID 8456624-(Trifluoromethoxy)benzalmalononitrileHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 22235037HCID 22235037, 화합물수율 60%

시약·촉매·용매 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 8028Tetrahydrofuran용매2회

실험 절차

Using 1.19 g of (4-(trifluoromethoxy)benzylidene)malononitrile 20 ml of tetrahydrofuran, a catalytic amount of copper (I) iodide, and 12.5 ml of a solution of methyl magnesium bromide in tetrahydrofuran (about 1 M, available from Tokyo Kasei Kogyo Co., Ltd), and according to the process described in Reference Production Example 2, there was obtained 0.76 g of (1-(4-(trifluoromethoxy)phenyl)ethyl)malononitrile (the intermediate (10)).

출처 및 근거

ORD 기록
ord-66c775e614454c1684ee70fde62bd387
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402691B2

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