Dimethyl Fumarate → Tetramethyl cyclobutane-1,2,3,4-tetracarboxylatato(2-)

HRID 749624

반응식

HRID 749624 반응식
[C:1]([O:9][CH3:10])(=[O:8])/[CH:2]=[CH:3]/[C:4]([O:6][CH3:7])=[O:5]>O>[CH:2]1([C:1]([O:9][CH3:10])=[O:8])[CH:3]([C:4]([O:6][CH3:7])=[O:5])[CH:2]([C:1]([O:9][CH3:10])=[O:8])[CH:3]1[C:4]([O:6][CH3:7])=[O:5]

참가 물질

3

반응물 1

HCID 637568Dimethyl Fumarate

생성물 1

HCID 266035Tetramethyl cyclobutane-1,2,3,4-tetracarboxylatato(2-)수율 100%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The dimethyl fumarate (1224 g, 8.5 mol) and water (4000 ml) were added to a 6-liter flask and irradiated by 365 nm ultraviolet lights at a temperature from 5 to 7° C. for 7 hours. The resultant solid in the flask was vacuum filtered to obtain tetramethyl cyclobutane-1,2,3,4-tetracarboxylate (1224 g, 4.25 mol). According to the NMR spectrum as shown in FIG. 1, dimethyl fumarate was present before the cyclization reaction. It can be observed from FIG. 2 that, after the cyclization reaction, the absorption peak at 6.77 ppm disappeared which means that dimethyl fumarate had been reacted completely. The absorption peak at 3.68 ppm represents the generation of the corresponding cyclobutanetetracarboxylate. FIGS. 1 and 2 prove that the yield of the reaction is almost 100%.

후처리

  1. customirradiated by 365 nm ultraviolet lights at a temperature from 5 to 7° C. for 7 hours
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-f40ef0cbe9bd4178bc07ea3448a2523f
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402693B2

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