Cesium carbonate → Methyl 5-(tert-butoxycarbonylamino)-1-methylcyclohex-3-enecarboxylate

HRID 74997노트

반응식

HRID 74997 반응식
[CH3:1][C:2]12[CH2:17][CH:6]([N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C:8]1=[O:9])[CH:5]=[CH:4][CH2:3]2.IC1C2CC(C)(C(=O)N2[C:27](OC(C)(C)C)=[O:28])CC=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CO>[C:13]([O:12][C:10]([NH:7][CH:6]1[CH2:17][C:2]([CH3:1])([C:8]([O:28][CH3:27])=[O:9])[CH2:3][CH:4]=[CH:5]1)=[O:11])([CH3:16])([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 68008024Tert-butyl 1-methyl-7-oxo-6-azabicyclo[3.2.1]oct-3-ene-6-carboxylateHCID 86667435Tert butyl 4-iodo-1-methyl-7-oxo-6-azabicyclo[3.2.1]oct-3-ene-6-carboxylate

생성물 1

HCID 67285544Methyl 5-(tert-butoxycarbonylamino)-1-methylcyclohex-3-enecarboxylate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of tert-butyl 1-methyl-7-oxo-6-azabicyclo[3.2.1]oct-3-ene-6-carboxylate, 52e, (4.93 g, 20.78 mmol) in MeOH (100 mL) was added cesium carbonate (13.54 g, 41.56 mmol). The reaction was stirred overnight and then concentrated in vacuo. The cesium salts were precipitated with Et2O and filtered. The ether filtrate was evaporated to give 5.5 g of a yellow oil that was used without further purification.

후처리

  1. concentrationconcentrated in vacuo
  2. customThe cesium salts were precipitated with Et2O
  3. filtrationfiltered
  4. customThe ether filtrate was evaporated

출처 및 근거

ORD 기록
ord-b4c8293e3e304bb4a76cf91d58d46185
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829007B2

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