Oxirane, 2-propyl- → 1-(4-Methanesulfonylbenzylamino)pentan-2-ol

HRID 750121

반응식

HRID 750121 반응식
[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[O:13]1[CH:15]([CH2:16][CH2:17][CH3:18])[CH2:14]1>CO>[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH:10][CH2:14][CH:15]([OH:13])[CH2:16][CH2:17][CH3:18])=[CH:7][CH:6]=1)(=[O:3])=[O:4]

참가 물질

4

반응물 2

HCID 13853Oxirane, 2-propyl-HCID 574214-Methylsulfonylbenzylamine

생성물 1

HCID 230607521-(4-Methanesulfonylbenzylamino)pentan-2-ol수율 34.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution (50 ml) of 4-methanesulfonylbenzylamine (5.0 g) and 1,2-epoxypentane (2.8 g) in methanol was stirred at room temperature for 96 hrs. The reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=10:1) to give the title compound (2.5 g).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe obtained residue was purified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=10:1)

출처 및 근거

ORD 기록
ord-2c44bf5e738b40f29830c347e2fc684b
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402595B2

연결된 노트

불러오는 중…