Methanol → 2-(2,3-dihydrobenzofuran-5-ylmethyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid

HRID 750157노트

반응식

HRID 750157 반응식
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:13][C:14]1[CH:15]=[CH:16][C:17]3[O:21][CH2:20][CH2:19][C:18]=3[CH:22]=1)[C:6]([C:23]([OH:25])=[O:24])=[C:5]2[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.CO.[H][H]>[C].[Pd].C1COCC1>[O:21]1[C:17]2[CH:16]=[CH:15][C:14]([CH2:13][N:7]3[C:6]([C:23]([OH:25])=[O:24])=[C:5]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:4]4[C:9](=[CH:10][CH:11]=[CH:2][CH:3]=4)[C:8]3=[O:12])=[CH:22][C:18]=2[CH2:19][CH2:20]1

참가 물질

6

반응물 3

HCID 887MethanolHCID 230608896-bromo-2-(2,3-dihydrobenzofuran-5-ylmethyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic AcidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 230609682-(2,3-dihydrobenzofuran-5-ylmethyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid수율 65.1%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 6-bromo-2-(2,3-dihydrobenzofuran-5-ylmethyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid (350 mg), 10% palladium carbon (150 mg), methanol (5 ml) and THF (5 ml) was stirred at room temperature under 1 atm hydrogen pressure for 12 hrs. Palladium carbon was filtered off, and the filtrate was concentrated. The obtained crystals were washed with diethyl ether to give the title compound (190 mg).

후처리

  1. filtrationPalladium carbon was filtered off
  2. concentrationthe filtrate was concentrated
  3. washThe obtained crystals were washed with diethyl ether

출처 및 근거

ORD 기록
ord-df7102cfa49c4d75aef0e7194ca9c4c2
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402595B2

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