1,4-Dioxane hydrochloride → 6-carbamoyl-2-(4-carboxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

HRID 750257노트

반응식

HRID 750257 반응식
O1CCOCC1.Cl.[CH3:8][O:9][C:10]([C:12]1[N:13]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([C:39]([O:41]C(C)(C)C)=[O:40])=[CH:35][CH:34]=2)[C:14](=[O:31])[C:15]2[C:20]([C:21]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[CH:19][C:18]([C:28](=[O:30])[NH2:29])=[CH:17][CH:16]=2)=[O:11]>>[CH3:8][O:9][C:10]([C:12]1[N:13]([CH2:32][C:33]2[CH:34]=[CH:35][C:36]([C:39]([OH:41])=[O:40])=[CH:37][CH:38]=2)[C:14](=[O:31])[C:15]2[C:20]([C:21]=1[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[CH:19][C:18]([C:28](=[O:30])[NH2:29])=[CH:17][CH:16]=2)=[O:11]

참가 물질

3

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 691570372-(4-tert-butoxycarbonylbenzyl)-6-carbamoyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

생성물 1

HCID 691567496-carbamoyl-2-(4-carboxybenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester수율 69%

실험 절차

To a 4N-hydrochloric acid dioxane solution (5 ml) was added 2-(4-tert-butoxycarbonylbenzyl)-6-carbamoyl-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester (140 mg), and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was concentrated under reduced pressure, and the obtained crystals were washed with methanol to give the title compound (86 mg).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washthe obtained crystals were washed with methanol

출처 및 근거

ORD 기록
ord-d49cd52b741947b0b91ed9626f7ae955
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402595B2

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