Hydrazine → HCID 178434464, 화합물

HRID 750486노트

반응식

HRID 750486 반응식
[NH2:1][NH2:2].[Cl:3][C:4]1[N:9]=[C:8](Cl)[C:7]([C:11](=O)[CH3:12])=[CH:6][N:5]=1>C1COCC1>[Cl:3][C:4]1[N:9]=[C:8]2[NH:1][N:2]=[C:11]([CH3:12])[C:7]2=[CH:6][N:5]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 212747081-(2,4-Dichloropyrimidin-5-yl)ethan-1-one

생성물 1

HCID 178434464HCID 178434464, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of hydrazine (Aldrich, 102.4 mg, 3.2 mmol) in THF (5 mL), 1-(2,4-dichloro-pyrimidin-5-yl)-ethanone (Example 21, 191 mg, 1 mmol) was added and the mixture was stirred at room temperature for 1 hour. The reaction was quenched with water (5 mL) and the mixture was extracted with EtOAc/THF(3×5 mL, 1:1 mixture of EtOAc:THF ). The extract was dried with sodium sulfate and concentrated to give a solid. 126 mg, 75%. MS (M+H)+, 169.

후처리

  1. customThe reaction was quenched with water (5 mL)
  2. extractionthe mixture was extracted with EtOAc/THF(3×5 mL, 1:1 mixture of EtOAc:THF )
  3. dry with materialThe extract was dried with sodium sulfate
  4. concentrationconcentrated
  5. customto give a solid

출처 및 근거

ORD 기록
ord-cd85f807f6cd471390676b6fb7a364c6
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405220B2

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