Hydrazine → HCID 178491797, 화합물

HRID 750487노트

반응식

HRID 750487 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]([C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:12]=2[O:18][CH3:19])=O)=[CH:4][N:3]=1.[NH2:20][NH2:21]>C1COCC1>[Cl:1][C:2]1[N:7]=[C:6]2[NH:20][N:21]=[C:9]([C:11]3[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:12]=3[O:18][CH3:19])[C:5]2=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 9321Hydrazine2회HCID 59753877(2,4-Dichloro-pyrimidin-5-yl)-(5-fluoro-2-methoxy-phenyl)-methanone

생성물 1

HCID 178491797HCID 178491797, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of (2,4-dichloro-pyrimidin-5-yl)-(5-fluoro-2-methoxy-phenyl)-methanone (602 mg, 2 mmol) in THF (8 m), hydrazine (Aldrich, 98%, 64 mg, 2 mmol) was added and the mixture was stirred for 20 minutes followed by a second portion of hydrazine (0.1 mL). The reaction finished in 5 minutes. The solvent was removed and the solid was washed with water/acetonitrile (3:1) to give a yellow solid. 456 mg, 82%. MS (M+H)+, 278.

후처리

  1. waitThe reaction finished in 5 minutes
  2. customThe solvent was removed
  3. washthe solid was washed with water/acetonitrile (3:1)
  4. customto give a yellow solid

출처 및 근거

ORD 기록
ord-cf00f8f22bcf4727a9704597d8d2e13c
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405220B2

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