참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Methylindole | HCID 7224 | — |
| 반응물 | Tetrahydrophthalic anhydride, cis- | HCID 98495 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | 6-(2-Methyl-1H-indole-3-carbonyl)-cyclohex-3-enecarboxylic acid | HCID 67316669 | 105.9% |
반응 단계
2-Methyl indole (50 mmol, 6.55 g) and AlCl3 (50 mmol, 7.3 g) were stirred in 500 mL DCE. cis-1,2,3,6-Tetrahydrophthalic anhydride (50 mmol, 7.6 g) was added and the reaction was heated to 65° C. for 6 h. The reaction was carefully quenched with 10 mL water and stirred overnight. The resulting red solid was filtered, washed with water, and dried to give 15 g of the sub-title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07405215B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_07 |
|---|
| ORD ID | ord-e4743badafe142ea82a1d09c6661b277 |
|---|
| 출처 메모 | uspto-grants-2008_07 |
|---|
